C. Cunningham

Integrating diverse statistical methods to analyse stage-discriminatory cell interactions in colorectal neoplasia

The paper develops spatial descriptors using mathematical tools to analyze cell interactions in colorectal cancer progression and demonstrates their utility in identifying disease-related pathways.

Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer

This paper shows that stress-induced Rab11a-exosomes carrying AREG promote cetuximab resistance in colorectal cancer by activating EGFR signaling in KRAS-wild type cells.

Single-cell transcriptional changes of artemisinin-sensitive K13C580 and artemisinin-resistant K13580Y Plasmodium falciparum upon dihydroartemisinin exposure

This study uses single-cell RNA sequencing to compare transcriptional changes in artemisinin-sensitive and resistant Plasmodium falciparum strains after dihydroartemisinin exposure, identifying metabolic and protein export differences and a potential therapeutic target.

Rat microbial biogeography and age-dependent lactic acid bacteria in healthy lungs

This study defines the microbial biogeography of healthy Fischer 344 rats across their lifespan and identifies age-dependent changes in lactic acid bacteria in the lungs.

Insect homolog of oxytocin/vasopressin associated with parenting of males but not females in a subsocial beetle

The paper investigates the role of inotocin, a homolog of oxytocin/vasopressin, in parenting behavior in the subsocial beetle Nicrophorus orbicollis, finding it associated with male but not female parenting.

Continuing decline of the eastern quoll in Tasmania

The paper analyzes eastern quoll population trends in Tasmania from 1985-2019, revealing a continued decline with significant reductions in the early 2000s and more recent periods.

Novel inhibitors of E. coli lipoprotein diacylglyceryl transferase are insensitive to resistance caused by lpp deletion

The paper identifies Lgt inhibitors that remain effective against E. coli even when lpp is deleted, showing Lgt is a robust antibacterial target.

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression

This study uses a tumor-on-a-chip platform to show that M1 macrophages inhibit tumor growth and angiogenesis, while M2 macrophages promote tumor migration and angiogenesis through distinct molecular mechanisms.

Glutamine deprivation regulates the origin and function of cancer cell exosomes

This study shows that glutamine deprivation increases exosome release from cancer cells, which promote tumor growth and blood vessel networks through Rab11a-dependent mechanisms.