Cell BiologybioRxiv
Initiation of fibronectin fibrillogenesis is an enzyme-dependent process
S. Melamed, S. Zaffryar-Eilot, E. Nadjar-Boger…·H. Wolfenson
This study identifies fibronectin oxidation by lysyl-oxidase enzymes as a force-independent nucleation step initiating fibrillogenesis, which is critical for cell adhesion and mechanosensing.
DOI 10.1016/j.celrep.2023.112473