ImmunologybioRxivPreprint
Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome
E. Neuwirt, G. Magnani, T. Cikovic…·O. Gross
A small molecule screen identifies tyrosine kinase inhibitors that cause lysosomal damage, leading to cell lysis and NLRP3 inflammasome activation via K+ efflux.
DOI 10.1101/2022.02.19.480941