BiophysicsbioRxiv
Allosteric communication in Class A β-lactamases occurs via Cooperative Coupling of Loop Dynamics
I. Galdadas, S. Qu, A. S. F. Oliveira…·S. Haider
This study identifies allosteric communication pathways in Class A β-lactamases using molecular dynamics simulations, showing how amino acid substitutions affect enzyme activity and antibiotic resistance.
DOI 10.7554/elife.66567