S. Haider

{Omega}-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

This study investigates how {Omega}-loop mutations in PDC-3 β-lactamase affect its active site dynamics and catalytic activity through molecular simulations.

Coupling between acid-sensing ion channel 1a and the monocarboxylate transporter family shapes cellular pH response

The paper identifies a functional interaction between ASIC1a and MCT1 that modulates proton sensitivity and desensitization, showing its role in glioblastoma cell survival and mouse lifespan.

Local nutrient addition drives plant biodiversity losses but not biotic homogenization in global grasslands

This study shows nutrient addition reduces plant diversity at local and larger scales equally, without causing biotic homogenization in global grasslands.

Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes

This study shows that overexpression of SAS-6 promotes ciliogenesis and cell invasion through YAP/TAZ pathway activation, linked to poor cancer prognosis.

Deciphering the co-evolutionary dynamics of L2 β-lactamases via Deep learning

This paper uses deep learning to analyze the co-evolutionary dynamics of L2 β-lactamases and their functional mechanisms.

Low land-use intensity buffers grasslands against future climate and inter-annual climate variability in a large field experiment

This study shows that low land-use intensity grasslands are more resilient to climate change than intensively managed ones, based on eight years of field experiments in Germany.

Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming

This study investigates how maternal androgen exposure affects placental development in a PCOS-like mouse model and identifies trophoblast dysfunction as a key mechanism.

Improving forest ecosystem functions by optimizing tree species spatial arrangement

The paper shows that increasing tree species spatial heterogeneity in forests improves litter decomposition and nitrogen cycling by 45%.

Oligomeric states of an Influenza-encoded PB1-F2 viroporin

This study identifies the tetrameric oligomeric state of PB1-F2 viroporin using molecular dynamics simulations and experimental comparisons, showing its role in mitochondrial permeation and apoptosis.

Pervasive mislocalization of pathogenic coding variants underlying human disorders

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

Structural Insights into Regulation of Insulin Expression Involving i-Motif DNA Structures in the Insulin-Linked Polymorphic Region.

This study investigates how sequence variants in the insulin-linked polymorphic region form i-motif and G-quadruplex DNA structures, which regulate insulin gene expression.

The Structural Role of N170 in Substrate-assisted Deacylation in KPC-2 β-Lactamase

This study investigates the structural role of N170 in substrate-assisted deacylation in KPC-2 β-lactamase, revealing its impact on drug binding and catalytic activity.

High within-tree leaf trait variation and its response to species diversity and soil nutrients

The paper quantifies intra-individual leaf trait variation in a subtropical forest and shows its complex interaction with soil nutrients and species diversity.

Genomic profiling and pre-clinical modelling of breast cancer leptomeningeal metastasis reveals acquisition of a lobular-like phenotype

This study analyzes genomic changes in breast cancer leptomeningeal metastasis using CSF samples, identifying unique genetic features and potential therapeutic targets.

Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

This study analyzes NSP10 variants in SARS-CoV-2 using genomic data and biophysical methods, finding limited functional changes and strong conservation in its interactions with NSP14 and NSP16.

Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

The paper investigates how gating interactions between loops in the L1 metallo-β-lactamase affect active site conformational changes and identifies key residues critical for enzyme activity.

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

This study shows that PSMC3IP and MND1 depletion increases PARP inhibitor sensitivity in mitotic cells through impaired D-loop formation and homology-directed repair.

Monkey Pox Virus (MPXV): Phylogenomics, Host-Pathogen Interactome, and Mutational Cascade

This study analyzes Monkeypox virus genome sequences to investigate its phylogenomics, host-pathogen interactions, and mutational patterns, identifying key proteins and mutations associated with evolutionary dynamics and host evasion.

Two ligand-binding sites on SARS-CoV-2 non-structural protein 1 revealed by fragment-based x-ray screening

This study identifies two ligand-binding sites on SARS-CoV-2 nsp1 using X-ray crystallography and fragment-based screening, offering a foundation for inhibitor development.

Fully Transient CRISPR/Cas12f system in plants capable of broad-spectrum resistance against Begomovirus

The paper develops a transient CRISPR/Cas12f system in plants that provides broad-spectrum resistance against Begomoviruses with high efficiency and reduced off-target effects.

ReSurveyGermany: Vegetation-plot time-series over the past hundred years in Germany

The paper compiles and harmonizes vegetation-plot resurvey data from Germany over almost 100 years, enabling analysis of biodiversity change and species distribution shifts.

Revealing druggable cryptic pockets in the Nsp-1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography

This study identifies druggable pockets in Nsp1 of SARS-CoV-2 and other β-coronaviruses using simulations and crystallography, showing potential for new inhibitors.

The human placenta shapes the phenotype of decidual macrophages.

This study identifies distinct macrophage phenotypes in human decidua basalis and parietalis, showing that placenta-derived trophoblasts induce a pregnancy-tolerant macrophage phenotype.

Ligand-induced unfolding mechanism of an RNA G-quadruplex

This study investigates the mechanism by which TMPyP4 induces unfolding of RNA G-quadruplexes using simulations and experiments, revealing a two-state interaction mechanism.

Structural dynamics of the β-coronavirus Mpro protease ligand binding sites

The paper compares ligand-binding sites of Mpro proteases from SARS-CoV2, SARS-CoV, and MERS-CoV using deep learning and Markov state models to assess structural dynamics and conservation.

Allosteric communication in Class A β-lactamases occurs via Cooperative Coupling of Loop Dynamics

This study identifies allosteric communication pathways in Class A β-lactamases using molecular dynamics simulations, showing how amino acid substitutions affect enzyme activity and antibiotic resistance.

Therapy-induced normal tissue damage promotes breast cancer metastasis

This study shows that chemotherapy-induced normal tissue damage promotes breast cancer metastasis through pro-tumourigenic factors and extracellular matrix remodeling.

Generation of human induced trophoblast stem cells

This study generates human induced trophoblast stem cells (hiTSC) from post-natal cells using reprogramming and fate conversion, enabling diverse genetic modeling of placental development and disease.

Conformational flexibility Of A Highly Conserved Helix Controls Cryptic Pocket Formation In FtsZ

The paper identifies cryptic pockets in M. tuberculosis FtsZ that bind coumarin analogues, revealing how conformational flexibility of the H7 helix enables these interactions.

Ancestry Influences on the Molecular Presentation of Tumours

This study examines how ancestry affects the mutational landscape of tumors across 12,774 samples, finding ancestry influences mutation counts, timing, and specific mutational signatures.