Active Transcription and Epigenetic Reactions Synergistically RegulateMeso-Scale Genomic Organization
A. Kant, Z. Guo, V. Vinayak, M. V. Neguembor, W. S. Li, V. Agrawal, E. Pujadas, L. M. Almassalha, V. Backman, M. Lakadamyali, M. P. Cosma, V. Shenoy
This study introduces a mesoscale model to show how transcription and epigenetic reactions regulate heterochromatin domain sizes, finding that transcription loss increases domain size and compaction.
bioRxiv · Apr 21, 2023Biophysics