V. Backman

Nuclear blebs are associated with destabilized chromatin packing domains

The paper investigates how nuclear blebs alter chromatin packing domains, finding fragmentation of nanoscopic heterochromatin domains within blebs.

Formamide denaturation of double-stranded DNA for fluorescence in situ hybridization (FISH) distorts nanoscale chromatin structure

This study shows that formamide in 3D FISH distorts nanoscale chromatin structure, while alternative methods like RASER-FISH and CRISPR-Sirius have minimal impact.

DNA density is a better indicator of a nuclear bleb than lamin B loss

The paper compares lamin B and DNA levels in nuclear blebs across cell types and perturbations, finding DNA concentration is more consistently reduced than lamin B levels.

Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism

This study shows that depleting lamins B1 and B2 changes chromatin mobility and gene expression through mesoscale-motion dependent mechanisms.

Active Transcription and Epigenetic Reactions Synergistically RegulateMeso-Scale Genomic Organization

This study introduces a mesoscale model to show how transcription and epigenetic reactions regulate heterochromatin domain sizes, finding that transcription loss increases domain size and compaction.

H3.1Cys96 oxidation by mitochondrial ROS promotes chromatin remodeling, breast cancer progression to metastasis and multi-drug resistance

The paper shows that mitochondrial H2O2 oxidizes H3.1 at Cys96, promoting chromatin remodeling, breast cancer metastasis, and drug resistance.

Exposure of mammary cells to lipid activates gene expression changes associated with ER-negative breast cancer via chromatin remodeling.

The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.

Physical and data structure of 3D genome

This paper proposes a tree-like data structure for the 3D genome to explain its physical properties and folding principles.

Spectral Contrast Optical Coherence Tomography Angiography Enables Single-Scan Vessel Imaging

This paper introduces a single-scan optical coherence tomography angiography method using spectral contrast to image vessels without requiring multiple acquisitions.

Multimodal interferometric imaging of nanoscale structure and macromolecular motion uncovers UV induced cellular paroxysm

This paper introduces a multimodal interferometric imaging platform to study nanoscale structure and macromolecular dynamics in live cells, revealing a new phenomenon called cellular paroxysm induced by UV light.

Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation

This study shows that extracellular cations alter nuclear shape and mechanics through heterochromatin formation, rescuing nuclear morphology in disease models.

Interphase chromatin as a self-returning random walk: Can DNA fold into liquid trees?

The paper proposes a self-returning random walk model to explain interphase chromatin structure, reconciling high contact frequency and structural heterogeneity.

Preservation of cellular nano-architecture by the process of chemical fixation for nanopathology

This study evaluates how cytological preparation affects nanoscale chromatin changes using PWS microscopy in cancer cell models, showing that modifications can preserve clinically relevant nanoscopic differences.

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

The paper shows that chromatin histone modifications affect nuclear rigidity and morphology independently of lamins, inducing or suppressing nuclear blebs through changes in chromatin compaction.