Author

E. Reading

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:E. coli· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. Russell Lewis· 2 shared D. Hammerschmid· 2 shared H. I. Zgurskaya· 2 shared J. C. Gumbart· 2 shared K. M. Kuo· 2 shared L. M. N. Shah· 2 shared M. R. Uddin· 2 shared P. J. Booth· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

B. Russell Lewis

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3 papers

Recent·Most cited

Mg2+-dependent mechanism of environmental versatility in a multidrug efflux pump

B. Russell Lewis, M. R. Uddin, K. M. Kuo, L. M. N. Shah, N. J. Harris, P. J. Booth, D. Hammerschmid, J. C. Gumbart, H. I. Zgurskaya, E. Reading

The paper investigates how Mg2+ and pH regulate the structural dynamics of AcrA in the AcrAB-TolC multidrug efflux pump, showing Mg2+ maintains structural mobility for optimal pump function across varying environments.

bioRxiv · Jun 10, 2024Biochemistry

Conformational restriction shapes inhibition of a multidrug efflux adaptor protein

B. Russell Lewis, M. R. Uddin, M. Moniruzzaman, K. M. Kuo, A. J. Higgins, L. M. N. Shah, F. Sobott, J. M. Parks, D. Hammerschmid, J. C. Gumbart, H. I. Zgurskaya, E. Reading

The paper investigates how an inhibitor restricts the conformational dynamics of AcrA, a multidrug efflux adaptor protein, to block drug signal transmission in E. coli.

bioRxiv · Dec 9, 2022Biochemistry

Perturbed structural dynamics underlie inhibition and altered specificity of the multidrug efflux pump AcrB

E. Reading, Z. Ahdash, C. Fais, V. Ricci, X. Wang-Kan, E. Grimsey, J. W. Stone, G. Malloci, A. M. Lau, H. Findlay, A. Konijnenberg, P. J. Booth, P. Ruggerone, A. V. Vargiu, L. J. V. Piddock, A. Politis

The paper investigates the structural dynamics of the AcrB efflux pump, showing how inhibitors and mutations affect its function and substrate specificity.

bioRxiv · Apr 27, 2020Biochemistry