A. Politis

This study uses HDX-MS to analyze structural dynamics of tβ1AR with different ligands, revealing ICL1 dynamics linked to GPCR activation and drug modality.

This paper uses integrative HDX-MS and ensemble modeling to quantify conformational states of the sugar transporter XylE under different conditions.

The paper investigates the structural dynamics of the AcrB efflux pump, showing how inhibitors and mutations affect its function and substrate specificity.

The paper uses HDX-MS, mutagenesis, and MD simulations to show that substrate binding and protonation drive conformational changes in a transporter, while inhibitors prevent this transition.

This study uses HDX-MS to show that ATP binding causes SecY to open and SecA to close, while ATP hydrolysis reverses this, supporting a Brownian ratchet mechanism for protein translocation.

The paper determines the structure and dynamics of CSN-CRL2 complexes using cryo-EM and mass spectrometry, revealing a stepwise activation mechanism.

This study identifies Y-acidic motifs recognized by KLC1TPR in kinesin-1, distinct from W-acidic motifs, and proposes a model for their differential activity promotion.

This study identifies and validates two conserved cardiolipin binding sites on the SecA-SecYEG complex, showing their role in ATP and PMF-driven protein secretion.

The paper investigates how membrane lipids affect the structure and function of the purine transporter UapA, showing that specific lipids stabilize its dimeric form and transport activity.