E. Rios

Pyruvate Oxidation Sustains B Cell Antigen-Specific Activation to Exacerbate MASH

This study shows that B cell pyruvate oxidation supports antigen-specific activation, driving inflammation and fibrosis in MASH.

Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory programpredicted to correct glucose dysregulation

The paper identifies that muscle calcium stress leads to cleavage of junctophilin1, resulting in a gene regulatory program that improves glucose utilization in myoblasts.