Author

G. Fredrickson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

X. Revelo· 5 shared F. Barrow· 4 shared H. Wang· 4 shared K. Florczak· 4 shared P. Parthiban· 3 shared A. Herman· 2 shared E. Ciske· 2 shared H. Nguyen· 2 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersImmunology

X. Revelo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Macrophage-derived CCL24 promotes fibrosis and worsens cardiac dysfunction during heart failure

P. Parthiban, F. Barrow, H. Nguyen, F. Neto, K. Florczak, H. Wang, D. Yucel, H. Liu, M. Draxler, E. Ciske, G. Fredrickson, A. Herman, M. Rothenberg, S. Dudley, J. H. van Berlo, X. Revelo

This study shows that macrophage-derived CCL24 worsens fibrosis and cardiac dysfunction in heart failure by activating fibroblasts through the CCR3 receptor.

bioRxiv · Jul 12, 2024 · PreprintImmunology

Pyruvate Oxidation Sustains B Cell Antigen-Specific Activation to Exacerbate MASH

F. Barrow, H. Wang, G. Fredrickson, K. Florczak, E. Ciske, S. Khanal, P. Parthiban, H. Nguyen, E. Rios, E. Kostallari, X. Revelo

This study shows that B cell pyruvate oxidation supports antigen-specific activation, driving inflammation and fibrosis in MASH.

bioRxiv · Nov 13, 2023 · PreprintPhysiology

Hepatic lipid-associated macrophages mediate the beneficial effects of bariatric surgery against MASH

G. Fredrickson, K. Florczak, F. Barrow, K. Dietsche, H. Wang, P. Parthiban, R. Almutlaq, O. Adeyi, A. Herman, A. Bartolomucci, C. Staley, C. Jahansouz, J. W. Williams, D. Mashek, S. Ikramuddin, X. Revelo

This study shows that bariatric surgery reduces MASH through TREM2-expressing hepatic macrophages, independent of weight loss.

bioRxiv · Jun 11, 2023 · PreprintPhysiology

Dysfunctional T Follicular Helper Cells Cause Intestinal and Hepatic Inflammation in NASH

H. Wang, F. Barrow, G. Fredrickson, K. Florczak, S. Ikramuddin, H.-B. Ruan, S. C. Jameson, X. Revelo

This study identifies dysfunctional T follicular helper cells in NASH as a driver of intestinal and hepatic inflammation using a mouse model.

bioRxiv · Jun 7, 2023 · PreprintImmunology

Trem2 Promotes Foamy Macrophage Lipid Uptake and Survival in Atherosclerosis

M. T. Patterson, M. M. Firulyova, Y. Xu, C. Bishop, A. Zhu, P. R. Schrank, C. E. Ronayne, G. Fredrickson, A. E. Kennedy, N. Acharya, X. Revelo, I. M. Stromnes, T. D. Bold, K. Zaitsev, J. W. Williams

This study identifies Trem2 as a regulator of foamy macrophage differentiation and atherosclerotic plaque growth, showing its role in lipid uptake and cell survival.

bioRxiv · Nov 28, 2022Immunology