Specific oncogene activation of the cell of origin in mucosal melanoma
S. Babu, J. Chen, E. Robitschek, C. S. Baron, A. McConnell, C. Wu, A. Dedeilia, M. Sade-Feldman, R. Modhurima, M. P. Manos, K. Y. Chen, A. M. Cox, C. G. Ludwig, J. Yang, M. Kellis, , M. L. Insco
This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.
bioRxiv · Apr 22, 2024Cancer Biology