C. Wu

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

TPM4 condensates glycolytic enzymes to fuel actin reorganization under hyperosmotic stress

The paper shows that TPM4 forms condensates with glycolytic enzymes under hyperosmotic stress, linking actin reorganization to metabolic activity.

Blebs regulate phosphoinositides distribution and promote cell survival through the Septin-SH3KBP1-PI3K axis

The paper shows blebs regulate phosphoinositides distribution via the Septin-SH3KBP1-PI3K axis, promoting cell survival during anoikis resistance.

Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries

This study uses live-cell single-molecule tracking in yeast to analyze the dynamics of RNA polymerase machineries, revealing new insights into transcriptional processes and the role of the CTD in splicing.

Identification of P-type ATPase as a bacterial transporter for host-derived small RNA

This study identifies a bacterial P-type ATPase transporter, PtaT, that specifically binds and mediates the uptake of host-derived tsRNAs in Fusobacterium nucleatum.

Macrophages facilitate interclonal cooperation-induced tumor heterogeneity and malignancy by activating the innate immune signaling

This study shows that macrophages in Drosophila tumors promote heterogeneity and malignancy by activating innate immune signaling through the Toll pathway.

PRR adjuvants restrain high stability peptides presentation on APCs

This study shows adjuvants like MPLA and CpG reduce high-stability peptide presentation on APCs, shifting T-cell immunodominant epitope responses.

Channel width modulates the permeability of DNA origami based nuclear pore mimics

The paper investigates how varying the width of DNA origami-based nuclear pore mimics affects permeability, showing that narrower pores restrict viral capsid passage while wider pores allow it with NTR assistance.

L-Shaped Distributions of the Relative Substitution Rates (c/micro) in SARS-COV-2 with or without Molecular Clocks, Challenging Mainstream Evolutionary Theories

The paper analyzes c/{micro} substitution rates in SARS-COV-2 genome segments, finding L-shaped distributions and molecular clocks that challenge existing evolutionary theories and propose new Near-Neutral Selectionist Theories.

Virtual Growing Child (VGC): A general normative comparative system via quantitative dynamic MRI for quantifying pediatric regional respiratory anomalies with application in thoracic insufficiency syndrome (TIS)

The paper introduces VGC, a normative database for pediatric respiratory measurements using MRI, to quantify regional respiratory anomalies in thoracic insufficiency syndrome patients.

Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

Specific oncogene activation of the cell of origin in mucosal melanoma

This study develops a zebrafish model of mucosal melanoma by activating an oncogene and inactivating tumor suppressors, revealing that internal melanocytes give rise to tumors with distinct transcriptional and chromatin features.

Current forest carbon offset buffer pools do not adequately insure against disturbance-driven carbon losses

The paper assesses current forest carbon offset buffer pools and finds they are insufficient to insure against disturbance-driven carbon losses in tropical forests.

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

This study shows that mechanical confinement triggers ferroptosis via mitochondrial dysfunction by inducing Drp1-dependent fragmentation and cPLA2 translocation.

IL-1beta-induced epithelial cell and fibroblast transdifferentiation fuels neutrophil recruitment in chronic rhinosinusitis with nasal polyps

This study identifies IL-1beta-induced cell subsets that promote neutrophil recruitment in CRSwNP and shows IL-1beta inhibition reduces inflammation.

Prevotella are major contributors of sialidases in the human vaginal microbiome.

This study identifies Prevotella as a major source of sialidases in the vaginal microbiome, showing their prevalence and activity compared to Gardnerella.

Exposure and resistance to lantibiotics impact microbiota composition and function

This study shows that lantibiotic resistance genes in gut bacteria affect microbiota composition and function, with implications for microbiome health and resistance strategies.

Impact of CRISPR/HDR-editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques

This study compares CRISPR/HDR and lentiviral transduction effects on HSPC engraftment and clonal dynamics in rhesus macaques, finding HDR-edited cells decline rapidly while lentiviral cells persist longer.

Structure basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

Effects of greening-induced warming and cooling on tree phenology in temperate and boreal forests

This study shows forest greening alters tree phenology by causing earlier spring and autumn events through seasonal biophysical warming and cooling effects.

Filter-aided expansion proteomics

The paper introduces FAXP, a method combining hydrogel expansion and mass spectrometry for high-resolution proteomics of FFPE tissues, showing improved resolution and efficiency over existing methods.

Efficacy of the first bioactive peptide from the pearl

The paper identifies a novel ACE-inhibitory peptide from pearl matrix and demonstrates its potential as an antihypertensive agent.

Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation

This study identifies RAP2 GTPase as a central integrator of cytoskeletal signals in Hippo pathway regulation, showing its role in mediating responses to cytoskeletal changes and its impact on Hippo kinase activity.

β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of femoral head

This study shows that β-catenin inhibition disrupts osteogenic/adipogenic differentiation in bone marrow mesenchymal cells, contributing to glucocorticoid-induced osteonecrosis of the femoral head.

Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation

This paper introduces Spiral NeuroString, high-density soft bioelectronic fibers for multimodal sensing and stimulation, demonstrating their use in GI motility mapping, serotonin sensing, and brain recordings.

Use of CRISPR interference for efficient and rapid gene inactivation in Fusobacterium nucleatum

This paper introduces a CRISPRi system for efficient gene inactivation in Fusobacterium nucleatum, demonstrating its effectiveness in both model and resistant strains.

Structure-Activity Relationship Studies of Novel Gut-derived Lantibiotics Against Human Gut Commensals

The paper characterizes six gut-derived nisin-like lantibiotics, evaluates their antimicrobial activity against pathogens and commensals, and identifies key residues affecting their activity.

SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients

This study examines immune responses in CoronaVac-vaccinated individuals after Omicron infection, showing enhanced antibody and cellular immunity compared to unvaccinated controls.

Formin tails act as a switch, inhibiting or enhancing processive actin elongation

The paper investigates how tail domains in formins regulate actin assembly through alternative splicing, showing that some tails inhibit processive elongation while others enhance it.

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.