BiochemistrybioRxiv
Rigidified Scaffolds for 3-Angstrom Resolution Cryo-EM of Small Therapeutic Protein Targets
R. Castells-Graells, K. Meador, M. A. Arbing…·T. O. Yeates
This paper demonstrates that rigidified scaffolds enable 3-angstrom resolution cryo-EM for small therapeutic proteins like KRAS, overcoming size limitations in structural characterization.
DOI 10.1073/pnas.2305494120