K. Meador

The paper designs a symmetry-broken tetrahedral protein cage by modifying subunits to display a single copy of an outward-facing domain.

The paper designs new protein cages using machine learning and fragment-based methods, reporting their structures and insights into assembly success and failure.

This paper demonstrates that rigidified scaffolds enable 3-angstrom resolution cryo-EM for small therapeutic proteins like KRAS, overcoming size limitations in structural characterization.