Cancer BiologybioRxivPreprint
ACSS2 Regulates HIF-2α Degradation through the E3-Ubiquitin Ligase MUL1 in Clear Cell Renal Cell Carcinoma
Z. A. Bacigalupa, W. A. Brown, E. S. Krystofiak…·W. K. Rathmell
This study shows ACSS2 promotes HIF-2 stability by preventing its interaction with MUL1, and inhibiting ACSS2 reduces HIF-2 levels and suppresses ccRCC growth.
DOI 10.1101/2022.04.21.489116