Author

E. Smits

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

A. Lin· 2 shared C. Deben· 2 shared F. Lardon· 2 shared M. Le Compte· 2 shared S. Van Laere· 2 shared S. Vanlanduit· 2 shared A. Bogaerts· 1 shared A. D. Ramirez Sanchez· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

A. Lin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

R. Moerkens, J. Mooiweer, E. Smits, M. Berg, A. D. Ramirez Sanchez, R. Modderman, J. Puschhof, C. Pleguezuelos-Manzano, R. J. Barrett, C. Wijmenga, I. H. Jonkers, S. Withoff

This study compares hiPSC-derived intestinal epithelial cells cultured in organoids, Transwells, and intestine-on-chip systems, showing that the latter promotes stronger gene expression related to nutrient and drug metabolism and a more mature state.

bioRxiv · Jun 30, 2024 · PreprintCell Biology

Uncovering the hidden threat: single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer

M. Le Compte, E. Cardenas De La Hoz, S. Peeters, F. Rodrigues Fortes, C. Hermans, A. Domen, E. Smits, F. Lardon, T. Vandamme, A. Lin, S. Vanlanduit, G. Roeyen, S. Van Laere, H. Prenen, M. Peeters, C. Deben

This study uses single-organoid analysis to identify treatment-resistant and invasive subclones in pancreatic cancer, correlating with patient outcomes and drug response.

bioRxiv · Feb 27, 2023 · PreprintCancer Biology

OrBITS: A High-throughput, time-lapse, and label-free drug screening platform for patient-derived 3D organoids

C. Deben, E. C. De La Hoz, M. Le Compte, P. Van Schil, J. M. Hendriks, P. Lauwers, S. K. Yogeswaran, F. Lardon, S. Van Laere, P. Pauwels, A. Bogaerts, E. Smits, S. Vanlanduit, A. Lin

The paper introduces OrBITS, a software for automated live-cell imaging of organoids, validated against standard assays, and demonstrates its utility in drug screening and patient stratification.

bioRxiv · Sep 9, 2021 · PreprintCancer Biology

Preexisting memory CD4 T cells in nÏave individuals confer robust immunity upon hepatitis B vaccination

G. Elias, P. Meysman, E. Bartholomeus, N. De Neuter, N. Keersmaekers, A. Suls, H. Jansens, A. Souquette, H. De Reu, E. Smits, E. Lion, P. G. Thomas, G. Mortier, P. Van Damme, P. Beutels, , B. Ogunjimi

The paper shows preexisting memory CD4 T cells in unvaccinated individuals correlate with stronger hepatitis B vaccine responses and predicts immune outcomes using TCR sequencing and machine learning.

bioRxiv · Aug 22, 2020Immunology