Author

E. Spear

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metagenomics· 1 Organism:yeast· 1

Frequent Co-Authors

E. P. Carpenter· 2 shared L. Nie· 2 shared S. Michaelis· 2 shared A. C. W. Pike· 1 shared A. Chu· 1 shared A. Quigley· 1 shared B. Rotty· 1 shared C. Hrycyna· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersBiochemistry

E. P. Carpenter

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Author profile →

3 papers

Recent·Most cited

Oomycete communities in lowland tropical forest soils vary in abundance and are composed of saprophytes and pathogens of seeds and seedlings of multiple plant species.

K. Broders, H. Capador-Barreto, G. Iriarte, J. Wright, M. Baur, H. Espinosa-Ortega, E. Spear

The paper assesses oomycete diversity and pathogenicity in lowland tropical forest soils, finding they are abundant, host-generalist pathogens and saprophytes affecting seed and seedling survival.

bioRxiv · Feb 25, 2024 · PreprintEcology

A new paradigm for Prelamin A proteolytic processing by ZMPSTE24: the upstream SY^LL cleavage occurs first and there is no CaaX processing by ZMPSTE24

L. Nie, E. Spear, T. D. Babatz, A. Quigley, Y. Y. Dong, A. Chu, B. Rotty, R. Chalk, S. M. M. Mukhopadhyay, N. A. Burgess-Brown, A. C. W. Pike, S. G. Young, S. Michaelis, E. P. Carpenter

This study challenges the established order of prelamin A processing by ZMPSTE24, showing that SY^LL cleavage occurs first and independently of C-terminal modifications.

bioRxiv · May 13, 2020 · PreprintBiochemistry

ZMPSTE24 Missense Mutations that Cause Progeroid Diseases Decrease Prelamin A Cleavage Activity and/or Protein Stability

E. Spear, E.-T. Hsu, L. Nie, E. P. Carpenter, C. Hrycyna, S. Michaelis

This paper identifies ZMPSTE24 missense mutations that impair prelamin A cleavage, classifying them into activity, stability, or dual defects and showing potential therapeutic rescue strategies.

bioRxiv · May 21, 2018Cell Biology