J. Wright

Oomycete communities in lowland tropical forest soils vary in abundance and are composed of saprophytes and pathogens of seeds and seedlings of multiple plant species.

The paper assesses oomycete diversity and pathogenicity in lowland tropical forest soils, finding they are abundant, host-generalist pathogens and saprophytes affecting seed and seedling survival.

Disentangling the age-dependent causal pathways affecting multiple paternity in house sparrows

This study uses Bayesian multi-level path analysis to disentangle age-dependent causal pathways affecting multiple paternity in house sparrows, finding age influences differ between males and females.

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-kappa B-regulated immune response.

This paper identifies PARP inhibitors as sensitizers for oncolytic reovirus by enhancing DISC-mediated apoptosis and NF-kappa B-driven immune responses.

Transcriptional profiling of peripheral blood mononuclear cells identifies inflammatory phenotypes in ataxia telangiectasia

This study uses bulk RNA-seq to identify inflammatory phenotypes in ataxia telangiectasia by analyzing peripheral blood mononuclear cells.

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

This study reports the cryo-EM structure of a TRAP transporter from Haemophilus influenzae, revealing its dimeric architecture, Na+ sites, and substrate binding site, supported by mutagenic and functional data.

The small-bat-in-summer paradigm: energetics and adaptive behavioural routines of bats investigated through a stochastic dynamic model

This paper develops a stochastic dynamic model to study how bats optimize energy use and foraging behavior at high latitudes, finding that photoperiod is the main factor limiting their distribution.

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

Immunological imprinting of humoral immunity to SARS-CoV-2 in children

This study examines immune responses to Omicron variants in children, finding weak initial antibody responses that improve with reinfection or vaccination, while cellular immunity remains robust across all groups.

Proteogenomic characterization of age and sex interactions in cardiac gene expression

This study uses proteogenomics to identify age and sex-dependent gene expression and splicing changes in mouse hearts, revealing sexual dimorphism in cardiac aging and regulatory networks.

A Fully Implantable Wireless Bidirectional Neuromodulation System for Mice

This paper presents a fully-implantable wireless neuromodulation system for mice capable of bidirectional signal exchange and long-term functionality.

Plasma microbiome in COVID-19 subjects: an indicator of gut barrier defects and dysbiosis

The paper analyzes plasma microbiome and permeability markers in COVID-19 patients and healthy controls, finding higher gut permeability and gram-negative bacteria abundance in patients.

Tet1 isoforms differentially regulate gene expression, synaptic transmission and memory in the mammalian brain.

This study identifies two Tet1 isoforms with distinct roles in gene expression, synaptic transmission, and memory in the mammalian brain.

Variation in the Gut Microbiota of Common Marmosets: Differences with Colony of Origin and Integration

This study compares gut microbiota differences between three marmoset colonies, showing diet has a greater impact on bacterial communities than housing integration.

Individual reversible plasticity as a genotype-level bet-hedging strategy

This paper models how genotype-level bet-hedging influences the optimal degree of phenotypic plasticity by reducing fitness variance across environmental conditions.

Formula alters preterm infant gut microbiota and increases its antibiotic resistance load

This study shows formula feeding increases antibiotic resistance gene load in newborns, particularly in preterm infants and those on antibiotics, compared to non-formula-fed infants.

Bet-hedging across generations can affect the evolution of variance-sensitive strategies within generations

The paper investigates how bet-hedging and variance-prone strategies evolve under different environmental conditions and predicts their favorability based on decision events and fitness accumulation patterns.

Generalists versus specialists in fluctuating environments: a bet-hedging perspective

The paper models how environmental variability affects phenotypic variation to maximize long-term fitness, showing generalists are favored under multiplicative fitness effects.

Rare Microbial Taxa Emerge When Communities Collide: Freshwater and Marine Microbiome Responses to Experimental Seawater Intrusion

This study examines how freshwater and marine microbial communities respond to seawater intrusion, finding that rare taxa play a key role in resilience during community coalescence.

An Artificial Intelligence Workflow for Defining Host-Pathogen Interactions

HRMAn is an open-source image analysis platform using machine learning to quantify host-pathogen interactions, demonstrating its ability to recognize and classify pathogen responses in Toxoplasma gondii and Salmonella typhimurium.

Short-term insurance versus long-term bet-hedging strategies as adaptations to variable environments

The paper examines how adaptive insurance and bet-hedging strategies interact in variable environments, showing that canalization is often favored over conservative bet-hedging.

CRISPR/Cas9-APEX-mediated proximity labeling enables discovery of proteins associated with a predefined genomic locus in living cells

This paper introduces a method to identify proteins associated with a specific genomic locus in living cells without requiring specific antibodies.

Single Cell Transcriptomics And Flow Cytometry Reveal Disease-Associated Fibroblast Subsets In Rheumatoid Arthritis

The paper identifies disease-associated fibroblast subsets in rheumatoid arthritis using single-cell transcriptomics and flow cytometry, revealing subset-specific markers and functional differences.