Spatial transcriptomics of T and B cell receptors uncovers lymphocyte clonal dynamics in human tissue.
C. Engblom, K. Thrane, Q. Lin, A. Andersson, H. Toosi, X. Chen, E. Steiner, G. Mantovani, M. Hagemann-Jensen, S. Saarenpaa, M. Jangard, J. Michaelsson, J. Hartman, J. Lagergren, J. E. Mold, , J. Frisen
This paper introduces Spatial VDJ, a spatial transcriptomics method that maps T and B cell receptors in human tissue, revealing clonal dynamics and spatial organization of lymphocytes.
bioRxiv · Nov 22, 2022 · PreprintImmunology