Q. Lin

An optimized somatic embryo transformation system assisted homozygous edited rubber tree generation method mediated by CRISPR/Cas9

This study develops a CRISPR/Cas9-based method to generate homozygous edited rubber tree plants by optimizing somatic embryo transformation and subculture procedures.

Shallow-water chemosymbiotic clams are a globally significant and previously overlooked carbon sink

This study identifies shallow-water chemosymbiotic clams as a significant, previously overlooked carbon sink in the Yellow Sea, contributing 43% of the region's sedimental carbon burial.

Excitable Rho dynamics drive cell contractions by sequentially inducing ERM protein-mediated actin-membrane attachment and actomyosin contractility

The paper shows Rho activity drives cell retractions by sequentially enhancing ERM-mediated actin-membrane attachment and NMII-dependent contractility.

IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infections

The paper identifies PD-L1+ neutrophils in severe viral respiratory infections, showing they have regulatory functions and are generated in the bone marrow via IFN-γ.

CLAIR: An integrated lipid database across multiple crop species

The paper constructs a comprehensive lipid metabolism gene database for nine oilseed crops by integrating multi-omics data and identifying 221 additional genes.

The number and pattern of viral genomic reassortments are not necessarily identifiable from segment trees

This paper shows that reassortment events in segmented viruses cannot be reliably inferred from segment trees alone, even with perfect data.

Molecular basis of Gabija anti-phage supramolecular assemblies

This study reveals the structure and function of the Gabija anti-phage system, showing GajA forms tetramers and GajAB forms octamers, with GajB enhancing DNA cleavage activity.

Characterization of m6A modifiers and RNA modifications in uterine fibroids

This study characterizes m6A modifiers and RNA modifications in uterine fibroids using RNA-seq, RT-qPCR, and mass spectrometry, finding limited differential expression despite heterogeneity.

Arl3 regulates ODA16-mediated intraflagellar transport in motile cilia biogenesis

The paper identifies Arl3 as a displacement factor that releases ODA16 from intraflagellar transport in Trypanosoma brucei.

Perturbomics of tumor-infiltrating NK cells

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

Therapeutic immune cell engineering with an mRNA : AAV-Sleeping Beauty composite system

The paper introduces a composite gene delivery system called MAJESTIC for efficient and stable engineering of therapeutic immune cells, showing improved cell viability and transgene expression compared to existing methods.

The Mechanism underlying B cell Developmental Dysfunction in Kawasaki Disease Based on Single-cell Transcriptomic Sequencing

This study uses single-cell transcriptomics to identify B cell developmental dysfunction in Kawasaki Disease, showing repression of immune processes and altered gene expression in HSPCs and B cells before treatment.

Single-cell transcriptomic analyses reveal the cellular and genetic basis of aquatic locomotion in scyphozoan jellyfish

The paper was withdrawn due to the need for additional experimental evidence and reorganization of data and writing.

Diversity and ecological function of urease-producing bacteria in the cultivation environment of Gracilariopsis lemaneiformis

This study isolates urease-producing bacteria from the cultivation environment of Gracilariopsis lemaneiformis and shows they enhance urea uptake and nitrogen assimilation by the macroalgae.

Characterization of the mIF4G domains in the RNA surveillance protein Upf2

This study identifies specific residues in the mIF4G domains of Upf2 that are critical for NMD activity and translation termination in yeast.

Spatial transcriptomics of T and B cell receptors uncovers lymphocyte clonal dynamics in human tissue.

This paper introduces Spatial VDJ, a spatial transcriptomics method that maps T and B cell receptors in human tissue, revealing clonal dynamics and spatial organization of lymphocytes.

Entropic control of the free energy landscape of an archetypal biomolecular machine

This study reveals how ligands modulate the free energy landscape of the bacterial ribosome by altering its structural flexibility, suggesting entropic control as a general mechanism for regulating biomolecular machines.

Simultaneous and sequential multi-species coronavirus vaccination

This study evaluates simultaneous and sequential multi-species coronavirus mRNA vaccination, showing sequential vaccination induces stronger antibody responses against SARS-CoV-2, SARS-CoV, and MERS-CoV.

Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

Potent and specific human monoclonal antibodies against SARS-CoV-2 Omicron variant by rapid mRNA immunization of humanized mice

This study develops RAMIHM, a method to generate potent human monoclonal antibodies against SARS-CoV-2 Omicron using mRNA immunization of humanized mice, identifying three highly effective antibodies.

The infiltration pattern of microenvironmental cells and different immune escape mechanisms in colorectal cancer

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

Comparative evaluation of glomerular morphometric techniques reveals differential technical artefacts between FSGS and normal glomeruli

This study evaluates glomerular morphometric techniques, finding that 10-glomerular sampling is sufficiently precise and that paraffin-embedding causes shrinkage bias affecting FSGS and normal glomeruli differently.

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

This study evaluates an Omicron-specific mRNA vaccine, showing it elicits strong antibody responses and outperforms WT boosters against Omicron and Delta variants.

Analysis of secondary metabolite gene clusters and chitin biosynthesis pathways of Monascus purpureus with high production of pigment and citrinin based on whole-genome sequencing

This study sequenced the genome of Monascus purpureus to identify secondary metabolite gene clusters and chitin synthesis pathways, and confirmed plasma-induced gene expression.

ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of liver cells

The paper identifies ASGR1 as a potential receptor for SARS-CoV-2 that facilitates liver cell infection and suggests soluble ASGR1 as a therapeutic target.

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance anti-HIV activity in vitro

This study develops allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv, showing enhanced anti-HIV activity in vitro compared to autologous CAR-T cells.

Selective inhibition of PfATP6 by artemisinins and identification of new classes of inhibitors after expression in yeast

The paper develops a yeast-based screening tool to identify PfATP6 inhibitors, confirming artemisinins target PfATP6 and discovering new inhibitor classes.

Microbial phylogenetic relatedness links to distinct successional patterns of bacterial and fungal communities

This study examines how microbial phylogenetic relatedness influences bacterial and fungal community succession patterns across a 54-year post-mining chronosequence.

Deep learning identifies pathological abnormalities predictive of graft loss in kidney transplant biopsies

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.

Intermittent KHz-frequency electrical stimulation selectively engages small unmyelinated vagal afferents

This study identifies intermittent KHz-frequency electrical stimulation (KES) as a method to selectively engage small unmyelinated vagal C-afferents in rats and mice.