Cell BiologybioRxivPreprint
Impaired HSF1 transactivation drives proteostasis collapse and senescent phenotype of IPF lung fibroblast.
K. Cuevas-Mora, W. Roque, D. Sales…·F. Romero
This study shows that impaired HSF1 transactivation leads to proteostasis collapse and senescent phenotype in IPF lung fibroblasts, suggesting HSF1 activation could treat lung fibrosis.