Burkholderia thailandensis methylated hydroxy-alkylquinolines: biosynthesis and antimicrobial activity in co-culture experiments
J. R. Klaus, C. Majerczyk, S. Moon, N. A. Eppler, S. Smith, E. Tuma, M.-C. Groleau, K. L. Asfahl, N. E. Smalley, H. Hayden, M. Piochon, P. Ball, A. A. Dandekar, C. Gauthier, E. Deziel, J. R. Chandler
This study identifies N-oxidated methyl-alkenylquinolines (HMAQ-NOs) as antimicrobial compounds produced by Burkholderia thailandensis, showing they are 50-fold more active than their non-oxidized counterparts against Bacillus subtilis.
bioRxiv · May 27, 2020Microbiology