S. Moon

Flotillin-2 dampens T cell antigen-sensitivity and functionality

This study shows that Flotillin-2 reduces T cell sensitivity to weak antigen stimulation by regulating TCR clustering and signaling.

Structural basis of aggregate binding by the AAA+ disaggregase ClpG

The paper determines the structure of the ClpG disaggregase's N1 domain, revealing how it recognizes and binds protein aggregates through hydrophobic interactions and Zn2+ coordination.

Automated cell annotation in multi-cell images using an improved CRF_ID algorithm

This paper improves the CRF_ID algorithm for multi-cell imaging in C. elegans, enhancing its accuracy and generalizability beyond whole-brain imaging.

A deep learning pipeline for segmentation of Proteus mirabilis colony patterns

This paper develops a deep learning pipeline to segment macroscopic colony patterns of Proteus mirabilis, achieving high accuracy in identifying colony boundaries and internal ring structures.

In vitro efficacy of Artemisia extracts against SARS-CoV-2

This study evaluates the in vitro antiviral efficacy of Artemisia extracts and a herbal drink against SARS-CoV-2 and FCoV, showing inhibition at non-toxic concentrations.

Measurements of acoustic radiation force of ultrahigh frequency ultrasonic transducers using model-based approach

The paper develops a model-based method to measure acoustic radiation force of ultrahigh frequency ultrasonic transducers using gelatin phantom experiments and validates it with FRET live cell imaging.

Burkholderia thailandensis methylated hydroxy-alkylquinolines: biosynthesis and antimicrobial activity in co-culture experiments

This study identifies N-oxidated methyl-alkenylquinolines (HMAQ-NOs) as antimicrobial compounds produced by Burkholderia thailandensis, showing they are 50-fold more active than their non-oxidized counterparts against Bacillus subtilis.

Dismantling and rebuilding the trisulfide cofactor demonstrates its essential role in human sulfide quinone oxidoreductase

This study demonstrates the essential role of the trisulfide cofactor in human sulfide quinone oxidoreductase by showing its critical impact on catalytic activity and rate enhancement.

Focused ultrasound stimulates ER localized mechanosensitive PANNEXIN-1 to mediate intracellular calcium release in invasive cancer cells

This study shows focused ultrasound activates ER-localized PANX1 in invasive cancer cells, triggering calcium release and cytokine release, suggesting a new adjuvant therapy for cancer immunotherapy.

A metal artifact reduction method for small field of view CT imaging.

This paper introduces a metal artifact reduction method for small field of view CT imaging that addresses data truncation, showing improved performance over existing methods using NMSE and SSIM metrics.

Graphene-enabled, spatially controlled electroporation of adherent cells for live-cell super-resolution microscopy

This paper introduces a graphene-based method for delivering fluorescent probes into live cells and performing super-resolution microscopy with high efficiency and spatial control.

Information-rich localization microscopy through machine learning

This paper introduces a machine learning approach to extract multidimensional information from single-molecule localization microscopy data without altering the point spread function.