Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation.
Y. Hari-Gupta, N. Fili, A. dos Santos, A. W. Cook, R. E. Gough, H. C. W. Reed, L. Wang, J. Arron, T. Venit, E. Waite, A. Grosse-Berkenbusch, J. C. M. Gebhardt, P. Percipalle, T. L. Chew, M. L. Martin-Fernandez, C. P. Toseland
This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.
bioRxiv · Apr 21, 2020Cell Biology