J. C. M. Gebhardt

This study identifies a mutation in IRF4 that alters DNA-binding specificity and gene regulation in lymphoma, leading to disease-specific gene up-regulation.

The paper uses single-molecule tracking to support the hindered diffusion model in zebrafish embryos by analyzing Nodal and Lefty diffusion dynamics.

The paper investigates TDP-43 mobility under stress and recovery, finding stress-induced mobility loss in cytoplasm and nucleus, independent of stress granules.

The paper investigates how transcription factor residence time affects transcriptional burst frequency and develops a model of gene transcription based on quantitative measurements.

The paper introduces TrackIt, a framework for single molecule tracking and analysis that addresses tracking errors and provides optimized parameters for reliable quantification of molecular dynamics.

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.

This study shows nuclear myosin VI moves along actin filaments and facilitates transcription-dependent chromatin rearrangements.

This paper introduces GRID, a method to infer dissociation rates and frequencies from single molecule survival time distributions, and applies it to study CDX2 dissociation from chromatin.