T. L. Chew

Specialized actin nanoscale layers control focal adhesion turnover

The paper identifies two new nanoscale actin layers in focal adhesions, showing their distinct roles in adhesion maturation and disassembly through Tpm1.6 and Tpm3.2.

Binding partners regulate unfolding of myosin VI to activate the molecular motor

This study investigates how binding partners regulate myosin VI unfolding and activation through biochemical and single-molecule analyses of splice isoforms.

Autophagy receptor NDP52 alters DNA conformation to modulate RNA Polymerase II transcription

This study identifies NDP52's role in modulating RNA Polymerase II transcription by altering DNA conformation through direct dsDNA binding and interactions with chromatin regulators.

The mycobacterial mutasome: composition and recruitment in live cells

This study identifies the molecular composition and function of the mycobacterial mutasome, showing that the ImuB-{beta} clamp interaction is essential for mutagenic DNA repair in mycobacteria.

Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

The paper identifies endothelial junctional membrane protrusions as preferred sites for neutrophil transmigration during inflammation and shows they depend on Rac1 activity.

Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation.

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.