R. E. Gough

This study investigates how binding partners regulate myosin VI unfolding and activation through biochemical and single-molecule analyses of splice isoforms.

This study investigates how mechanical forces affect talin-vinculin interactions, showing that force exposure of a vinculin binding site relieves vinculin autoinhibition and enhances binding affinity.

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.