Immune cells employ intermittent integrin-mediated traction forces for 3D migration
T. Czerwinski, L. Bischof, D. Böhringer, S. Kara, P. L. Strissel, R. Strick, A. Winterl, R. Gerum, E. Wittmann, M. Schneider, M. W. Beckmann, G. Nusser, M. Wiesinger, S. Budday, A. Lux, , C. Mark
This study shows immune cells switch between amoeboid and contractile migration modes in dense matrices, using integrin-mediated forces to navigate steric hindrance.
bioRxiv · Apr 20, 2023Biophysics