Author

A. Lux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Approach:statistical model· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

F. Nimmerjahn· 3 shared A. S. Meyer· 2 shared M. Biburger· 2 shared S. Kara· 2 shared A. E. H. Bentlage· 1 shared A. F. Brandner· 1 shared A. R. Cruz· 1 shared A. Winterl· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersImmunology

F. Nimmerjahn

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates

Z. C. Tan, A. Lux, M. Biburger, P. Varghese, S. Lees, F. Nimmerjahn, A. S. Meyer

This study examines how mixed Fc domain immune complexes bind Fc receptors, showing blended binding profiles and refined affinity estimates for low-affinity interactions.

Cell Reports · Jul 1, 2023Peer-reviewedImmunology

Role of lipid nanodomains for inhibitory FcγRIIb function

F. Spiegel, M. F. W. Trollmann, S. Kara, M. Pöhnl, A. F. Brandner, F. A. Nimmerjahn, A. Lux, R. A. Böckmann

This study investigates the lipid environment and conformational dynamics of FcγRIIb and its I232T variant using simulations and assays, finding that they interact with specific lipids rather than lipid rafts and that multivalent IgG complexes may stabilize receptor function.

bioRxiv · May 9, 2023 · PreprintImmunology

Immune cells employ intermittent integrin-mediated traction forces for 3D migration

T. Czerwinski, L. Bischof, D. Böhringer, S. Kara, P. L. Strissel, R. Strick, A. Winterl, R. Gerum, E. Wittmann, M. Schneider, M. W. Beckmann, G. Nusser, M. Wiesinger, S. Budday, A. Lux, , C. Mark

This study shows immune cells switch between amoeboid and contractile migration modes in dense matrices, using integrin-mediated forces to navigate steric hindrance.

bioRxiv · Apr 20, 2023Biophysics

Staphylococcal protein A inhibits IgG-mediated phagocytosis by blocking the interaction of IgGs with FcγRs and FcRn

A. R. Cruz, A. E. H. Bentlage, R. Blonk, C. J. C. d. Haas, P. C. Aerts, L. M. Scheepmaker, I. G. Bouwmeester, A. Lux, J. A. G. v. Strijp, F. Nimmerjahn, K. P. M. v. Kessel, G. Vidarsson, S. H. M. Rooijakkers

bioRxiv · Jan 21, 2022 · PreprintMicrobiology

Dissecting FcγR Regulation Through a Multivalent Binding Model

R. A. Robinett, N. Guan, A. Lux, M. Biburger, F. Nimmerjahn, A. S. Meyer

This paper develops a multivalent binding model to predict FcγR-immune complex interactions and enables rational design of immune complexes for desired effector functions.

bioRxiv · Nov 27, 2017Immunology