Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility
D. Boehringer, A. Bauer, I. Moravec, L. Bischof, D. Kah, C. Mark, T. J. Grundy, E. Goerlach, G. M. O'Neill, S. Budday, P. Strissel, R. Strick, A. Malandrino, R. Gerum, M. Mak, , B. Fabry
This study uses fiber alignment and density in 3D collagen networks as a proxy for cell traction forces, validated in hepatic stellate cells and glioblastoma cell lines, and provides an open-source tool for drug screening.
bioRxiv · Jun 28, 2023Biophysics