Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation
C. J. Queval, A. Fearns, L. Botella, A. Smyth, L. Schnettger, M. Mitermite, E. Wooff, B. Villareal-Ramos, W. Garcia-Gimenez, T. Heunis, M. Trost, D. Werling, F. J. Salguero, S. V. Gordon, M. Gutierrez
This study compares macrophage responses to human- and animal-adapted tuberculosis pathogens, identifying factors that drive multinucleated cell formation in bovine macrophages infected with M. bovis.
bioRxiv · Jul 2, 2020Microbiology