Author

L. Botella

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

A. Fearns· 1 shared A. Smyth· 1 shared B. Aylan· 1 shared B. Villareal-Ramos· 1 shared C. Bussi· 1 shared C. J. Queval· 1 shared D. Werling· 1 shared E. M. Bernard· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

A. Fearns

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Visualizing pyrazinamide action by live single cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis

P. Santucci, B. Aylan, L. Botella, E. M. Bernard, C. Bussi, E. Pellegrino, N. Athanasiadi, M. G. Gutierrez

This paper uses live-cell imaging to show that pyrazinamide disrupts Mycobacterium tuberculosis intracellular pH homeostasis, unlike other antibiotics, and that this effect depends on host endolysosomal acidification and PncA activity.

bioRxiv · Dec 20, 2021Microbiology

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

C. J. Queval, A. Fearns, L. Botella, A. Smyth, L. Schnettger, M. Mitermite, E. Wooff, B. Villareal-Ramos, W. Garcia-Gimenez, T. Heunis, M. Trost, D. Werling, F. J. Salguero, S. V. Gordon, M. Gutierrez

This study compares macrophage responses to human- and animal-adapted tuberculosis pathogens, identifying factors that drive multinucleated cell formation in bovine macrophages infected with M. bovis.

bioRxiv · Jul 2, 2020Microbiology