Author

A. Fearns

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. G. Gutierrez· 3 shared A. Rodgers· 2 shared C. J. Queval· 2 shared D. Greenwood· 2 shared H. Jiang· 2 shared M. Gutierrez· 2 shared M. Trost· 2 shared P. Santucci· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

M. G. Gutierrez

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

C. Bussi, T. Heunis, E. Pellegrino, E. M. Bernard, N. Bah, M. Silva Dos Santos, P. Santucci, B. Aylan, A. Rodgers, A. Fearns, J. Mitschke, C. Moore, J. I. MacRae, M. Greco, T. Reinheckel, , M. G. Gutierrez

This study shows lysosomal damage leads to mitochondrial proteome changes and metabolic reprogramming in macrophages, affecting immune responses to infections.

bioRxiv · Aug 9, 2022Cell Biology

Intracellular localisation of Mycobacterium tuberculosis affects antibiotic efficacy

P. Santucci, D. Greenwood, A. Fearns, K. Chen, H. Jiang, M. G. Gutierrez

This study investigates how the intracellular localization of Mycobacterium tuberculosis affects the efficacy of the antibiotic pyrazinamide (PZA) using multimodal microscopy techniques.

bioRxiv · Nov 25, 2020Microbiology

Correlative Light Electron Ion Microscopy reveal in vivo localisation of bedaquiline in Mycobacterium tuberculosis infected lungs

A. Fearns, D. Greenwood, A. Rodgers, H. Jiang, M. Gutierrez

The paper uses CLEIMiT to show bedaquiline accumulates in specific cell types in M. tuberculosis infected lungs.

bioRxiv · Aug 5, 2020Microbiology

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

C. J. Queval, A. Fearns, L. Botella, A. Smyth, L. Schnettger, M. Mitermite, E. Wooff, B. Villareal-Ramos, W. Garcia-Gimenez, T. Heunis, M. Trost, D. Werling, F. J. Salguero, S. V. Gordon, M. Gutierrez

This study compares macrophage responses to human- and animal-adapted tuberculosis pathogens, identifying factors that drive multinucleated cell formation in bovine macrophages infected with M. bovis.

bioRxiv · Jul 2, 2020Microbiology

Mycobacterium tuberculosis cording in the cytosol of live lymphatic endothelial cells

T. R. Lerner, C. J. Queval, R. P. Lai, M. R. G. Russell, A. Fearns, D. J. Greenwood, L. Collinson, R. J. Wilkinson, M. G. Gutierrez

This study shows that Mycobacterium tuberculosis forms intracellular cords in human lymphatic endothelial cells, evading xenophagy via the ESX-1 system and PDIM lipid.

bioRxiv · Apr 1, 2019 · PreprintCell Biology