D. Werling

Multi-omics analysis reveals regime shifts in the gastrointestinal ecosystem in chickens following anticoccidial vaccination and Eimeria tenella challenge

This study uses multi-omics analysis to identify shifts in the chicken gastrointestinal ecosystem following vaccination and Eimeria tenella challenge, revealing distinct metabolic and microbial profiles associated with health, infection, and recovery.

M. bovis PPD Enhances Respiratory Bioenergetics of Human vs. Bovine Macrophages

This study compares the respiratory bioenergetics of human and bovine macrophages in response to M. bovis PPD and other TLR ligands, finding species-specific metabolic changes only in human macrophages.

Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand

This study characterizes bovine Mincle, showing structural and functional similarity to human Mincle, with potential endogenous ligand recognition.

The tendon interfascicular basement membrane provides a vascular niche for CD146+ pericyte cell subpopulations

This study identifies CD146+ pericyte subpopulations in the tendon interfascicular basement membrane as a vascular niche involved in tendon structure and function, but not stem cell-like properties.

Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria

This study identifies genes required for Mycobacterium bovis survival in cattle using transposon insertion sequencing, revealing both known and novel virulence factors.

A novel whole yeast-based subunit oral vaccine against Eimeria tenella in chickens

The paper develops a whole yeast-based oral vaccine against Eimeria tenella in chickens, showing reduced parasite replication and improved weight gain in vaccinated birds.

Probing differences in gene essentiality between the human and animal adapted lineages of the Mycobacterium tuberculosis complex using TnSeq

This study compares gene essentiality between Mycobacterium bovis and Mycobacterium tuberculosis using transposon sequencing and CRISPRi, finding species-specific differences in essential genes and their functional roles.

Single Nucleotide Polymorphisms in the Bovine TLR2 Extracellular Domain Contribute to Breed and Species-Specific Innate Immune Functionality

This study identifies a SNP in bovine TLR2 that contributes to breed-specific differences in innate immune response to mycobacterial antigens.

Development of a yeast-based vaccine for Theileria parva infection in cattle

This paper develops a yeast-based vaccine for Theileria parva infection using recombinant antigens expressed on Saccharomyces cerevisiae, showing immune responses in mice and potential for oral application.

Bovine neutrophils release extracellular traps and cooperate with macrophages in Mycobacterium avium subsp. paratuberculosis clearance in vitro

This study investigates how bovine neutrophils and macrophages interact to clear Mycobacterium avium subsp. paratuberculosis in vitro, showing synergistic effects and reduced inflammation.

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

This study compares macrophage responses to human- and animal-adapted tuberculosis pathogens, identifying factors that drive multinucleated cell formation in bovine macrophages infected with M. bovis.

Escape of TLR5 Recognition by Leptospira spp: A Rationale for Atypical Endoflagella

This study investigates TLR5 recognition of Leptospira spp. and finds that their flagellins are highly stable and centrally located, allowing them to evade TLR5 detection.