A Targeted Vaccine against COVID-19: S1-Fc Vaccine Targeting the Antigen-Presenting Cell Compartment Elicits Protection against SARS-CoV-2 Infection
A. Herrmann, J. Maruyama, C. Yue, C. Lahtz, H. Zhou, L. Kerwin, W. Guo, Y. Zhang, W. Soo Hoo, S. Yei, S. Kwon, Y. Fu, S. Johnson, A. Ledesma, Y. Zhuang, , H. Ji
This paper develops a S1-Fc vaccine targeting antigen-presenting cells, showing it elicits protective anti-SARS-CoV-2 IgG and T cell responses, with high protection at low doses.
bioRxiv · Jun 29, 2020 · PreprintMicrobiology