Y. Zhuang

The paper constructs a spatially-resolved single-cell atlas of the ascidian endostyle, identifying new cell types and evolutionary insights into vertebrate pharyngeal organs.

This study uses symmetry-adapted Markov state modeling to analyze conformational transitions in α7 nAChRs, revealing lipid modulation effects and asymmetric transition pathways between functional states.

This study presents cryo-EM structures of the human ρ1 GABAAR under different conditions, revealing structural mechanisms of gating and modulation with implications for pharmaceutical design.

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.

This study reports cryo-EM structures of all human dopamine receptor subtypes bound to Rotigotine, revealing binding modes, activation mechanisms, and G-protein coupling specificity for drug design.

This study uses ancient DNA to trace tiger evolution, revealing China as a genetic melting pot and resolving taxonomic disputes among tiger subspecies.

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

This study characterizes the functional states of the α7 nicotinic acetylcholine receptor using computational methods, revealing state-dependent interactions with lipids and ligands.

This study shows AlphaFold2 and RoseTTAFold can predict whether GFP-like proteins will form a chromophore based on sequence alone, using structural and chemical insights.

This paper uses nanopillar arrays to quantify subnuclear morphology in tumor cells, showing it correlates with malignancy and drug response.

This study investigates the effect of moxibustion on colorectal cancer liver metastasis using animal models, finding reduced metastasis rates and identifying potential molecular targets.

This study identifies Zfp335 as a transcription factor that regulates survival of post-β-selection DN4 thymocytes by suppressing cGAS/STING-dependent apoptosis.

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

The paper presents cryo-EM structures of the ghrelin receptor bound to ghrelin and GHRP-6, revealing the binding pocket for the octanoyl group and providing insights for drug design.

This study investigates the SARS-CoV-2 E protein's effects on membrane curvature and intracellular calcium, using experimental and computational methods.

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

This study shows that RIPK3 phosphorylation at S165/T166 switches its function from necroptosis to apoptosis, driving corpus luteum regression via PGF2-induced apoptosis.

The paper reports cryo-EM structures and simulations of GLIC under different pH conditions, revealing conformational changes and electrostatic remodeling during proton-induced gating.

The paper uses genomic data to classify the Chinese mountain cat as a wildcat subspecies and finds no evidence of its role in domestic cat domestication in East Asia.

The paper describes the biosynthesis of new cinnamid and rosmarinic acid-derived compounds in E. coli that inhibit Leishmania amazonensis arginase, with some compounds showing micromolar inhibition.

The paper examines the relationship between SARS-CoV-2 specific T cell responses and disease severity in COVID-19 patients, finding that early T cell induction correlates with mild disease and faster viral clearance.

This study identifies miR775 as a regulator of leaf size in Arabidopsis by silencing GALT9, a galactosyltransferase that affects cell wall pectin levels and elasticity.

This study identifies PFKM as a direct target of celastrol, showing that its inhibition promotes weight loss and leptin sensitivity through AMPK/ACC signaling.

This study shows that the intrinsically disordered region of FBP17, not its F-BAR domain, is responsible for curvature sensing in membrane dynamics.

The paper identifies a PIF1-MIR408-PLC repression cascade that links light-induced PIF1 degradation to hormonal changes, regulating seed germination in Arabidopsis.

This paper develops a S1-Fc vaccine targeting antigen-presenting cells, showing it elicits protective anti-SARS-CoV-2 IgG and T cell responses, with high protection at low doses.

The paper uses cryo-EM and simulations to characterize the resting and activating states of GLIC, revealing structural changes and energy landscape dynamics.

This study identifies signature microbiota linked to rumen function shifts in goat kids due to solid diet supplementation using machine learning and functional analysis.