S. Kwon

Broad-scale phenotyping in Arabidopsis reveals varied involvement of RNA interference across diverse plant-microbe interactions

The paper investigates the role of RNA interference in Arabidopsis by analyzing AGO and DCL mutants against various pathogens and a mutualist, revealing both positive and neutral effects on immunity and colonization.

Stereotypic persistent B cell receptor clonotypes in Alzheimer's Disease

The paper identifies stereotypic BCR clonotypes in Alzheimer's Disease patients that persist over time and are not found in healthy controls, suggesting potential diagnostic signatures.

Structure and heterogeneity of a highly cargo-loaded encapsulin shell

The paper reports the cryo-EM structure of a highly cargo-loaded encapsulin shell and identifies structural distortions caused by high cargo loading.

An ancestral vaccine induces anti-Omicron antibodies by hypermutation

This study shows that repeated mRNA vaccination leads to BCR hypermutation, enabling antibodies to neutralize Omicron variants.

3D Graph Contrastive Learning for Molecular Property Prediction

This paper introduces a small-scale 3D Graph Contrastive Learning framework for molecular property prediction, achieving state-of-the-art results with limited resources and 3D structural information.

A Novel Mouse Model that Recapitulates the Heterogeneity of Human Triple Negative Breast Cancer

This paper develops a novel mouse model of TNBC by combining MYC amplification and PTEN deletion, showing it recapitulates human TNBC heterogeneity through omic analyses.

Existence of blood circulating immune-cell clusters (CICs) comprising antigen-presenting cells and B cells

The paper identifies circulating immune-cell clusters (CICs) composed of antigen-presenting cells and B cells in blood, showing increased frequency in COVID-19 patients.

One-step pipetting of barcoded planar microparticles into compact monolayer assembling chip for efficient readout of multiplexed immunoassay

The paper presents a microfluidic chip for efficient multiplexed immunoassay readout using barcoded planar microparticles, achieving good accuracy with a single pipetting step.

Robust hydrogel-integrated microsystems enabled by enhanced interfacial bonding strength

This paper introduces a mucosa-inspired bonding method to enhance the mechanical robustness of noncovalent hydrogels by bonding them to tough hydrogels without chemical modification.

Protein-based RBD-C-tag COVID-19 Vaccination Candidate Elicits Protection Activity against SARS-COV-2 Variant Infection

This study shows that a protein-based RBD-C-tag vaccine candidate provides protection against multiple SARS-COV-2 variants in mice.

A Targeted Vaccine against COVID-19: S1-Fc Vaccine Targeting the Antigen-Presenting Cell Compartment Elicits Protection against SARS-CoV-2 Infection

This paper develops a S1-Fc vaccine targeting antigen-presenting cells, showing it elicits protective anti-SARS-CoV-2 IgG and T cell responses, with high protection at low doses.

Stereotypic Neutralizing VH Clonotypes Against SARS-CoV-2 RBD in COVID-19 Patients and the Healthy Population

The paper identifies stereotypic VH clonotypes against SARS-CoV-2 RBD in patients and healthy individuals, showing their pre-existing presence in the healthy population.

DNA micro-disk for the management of DNA-based data storage with index and write-once-read-many (WORM) memory features

This paper introduces DNA micro-disks with index and WORM memory features to improve DNA-based data storage reliability and accessibility.

Differential risk of incident cancer in patients with heart failure: A nationwide population-based cohort study

This study finds that patients with heart failure have a higher risk of developing cancer compared to the general population, with increased risk observed across multiple cancer types.

HER2 Cancer Protrusion Growth Signaling Regulated by Unhindered, Localized Filopodial Dynamics

This study investigates how HER2 dynamics in filopodia regulate protrusion growth and signaling in breast cancer cells, revealing distinct motion patterns and functional roles in protrusion-based signaling.

Synthetic Biology Research and Innovation Profile 2018: Publications and Patents

The paper analyzes synthetic biology publications and patents globally from 2000 to 2018, examining growth, leading countries, organizations, and patenting trends.

High-throughput retrieval of physical DNA for NGS-identifiable clones in phage display library

The paper introduces a high-throughput platform, TrueRepertoire, for accurate clone identification and retrieval in phage display libraries, validated on a human hepatocyte growth factor-targeting scFv library.

Evaluating Tumor Evolution via Genomic Profiling of Individual Tumor Spheroids in a Malignant Ascites from a Patient with Ovarian Cancer Using a Laser-aided Cell Isolation Technique

The paper uses genomic profiling of tumor spheroids from malignant ascites to evaluate tumor evolution in an ovarian cancer patient, finding genetic differences between primary tumor and spheroids.