Pharmacology & ToxicologybioRxiv
The linear and non-linear effects of CYP2C19 metaboliser status on DNA methylation: a methylome-wide association study
Chen Shen, Mark J. Adams, Eleanor Davyson…·Xueyi Shen
This study investigates how CYP2C19 metaboliser status affects DNA methylation across the genome, finding 48 CpG sites associated with both linear and non-linear effects, linked to drug metabolism and inflammation.
DOI 10.1186/s13148-026-02125-w