Cell BiologybioRxivPreprint
Muscle stem cells produce a protective Fibrillin-1 matrix to prevent precocious activation.
Eleni Chrysostomou, Oussama Smail, Artemis Vlachopoulou…·Philippos Mourikis
This paper identifies Fibrillin-1 as a Notch-regulated matrix protein that maintains muscle stem cell quiescence by shielding them from mitogenic signals, and shows its loss leads to muscle dysfunction in Marfan syndrome.