Long-term dysregulation of histone acetylation, BDNF expression, and the hippocampal transcriptome in adult rats exhibiting a depressive-like phenotype following repeated chlorpyrifos exposure
Ana C.R. Ribeiro-Davis, Elisa Hawkins, Fay Jahr…·Laxmikant S Deshpande
This study shows that repeated chlorpyrifos exposure in rats leads to long-term epigenetic and transcriptional changes in the hippocampus, including reduced BDNF and altered neuronal plasticity pathways, associated with a depressive-like phenotype.