Cell BiologybioRxivPreprint
Hematopoietic Stem and Progenitor Cell Aging is Initiated at Middle Age Through Decline in Local Insulin-Like Growth Factor 1 (IGF1)
Kira Young, Elizabeth Eudy, Rebecca Bell…·Jennifer Trowbridge
This study identifies declining IGF1 production in the bone marrow microenvironment as a driver of hematopoietic stem cell aging starting in middle age in mice.
DOI 10.1101/2020.07.11.198846