Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation
Meenakshi Venkatasubramanian, Leya Schwartz, Nandini Ramachandra…·Nathan Salomonis
The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.