MicrobiologyACS Infectious DiseasesPeer-reviewed
A multiplexed, target-based phenotypic screening platform using CRISPR interference in Mycobacterium abscessus
Donavan Marcus Neo, Ishay Ben-Zion, Josephine Bagnall…·Deborah Tan Hung
This paper introduces a CRISPRi-based PROSPECT platform for drug discovery in M. abscessus, identifying new compound targets and revealing unexpected susceptibility to isoniazid.
DOI 10.1021/acsinfecdis.5c00623