NeurosciencebioRxivPreprint
The phosphorylation status of LRRK2 at the S910/S935 cluster determines its sensitivity to activation by RAB29
Antonio Jesús Lara Ordóñez, Chloé Annicotte, Enna Behrends…·Jean‐Marc Taymans
This study shows that dephosphorylation of LRRK2 at the S910/S935 cluster increases its sensitivity to activation by RAB29, leading to hyperactivation and centrosome cohesion deficits.
1 citation