Christian Galicia

This study shows that dephosphorylation of LRRK2 at the S910/S935 cluster increases its sensitivity to activation by RAB29, leading to hyperactivation and centrosome cohesion deficits.

The paper reports cryo-EM structures of the MnmE-MnmG complex in different oligomeric states, revealing conformational changes and a mechanism for substrate and cofactor transfer during tRNA modification.

This study develops a high-affinity DARPin that binds to LRRK2's WD40 domain, improving structural analysis and revealing its role in disrupting LRRK2 filaments and Rab8A phosphorylation.

This paper solves the structure of a bacterial Roco protein in its GTP-bound state using cryo-EM and nanobodies, revealing conformational changes and allosteric activation mechanisms.