Molecular BiologyScience AdvancesPeer-reviewed
The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome
Sarah J. Shemtov, Eric G. McGann, Lucy Carrillo…·Marc Vermulst
This study shows that reduced IGF-1 signaling extends lifespan in mammals but not in mitochondrial mutator mice, indicating that mitochondrial genome stability is essential for the longevity benefits of IGF-1 suppression.
DOI 10.1126/sciadv.aea4279