Author

F. Aksit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:structural biology· 3 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Organism:virus· 1

Frequent Co-Authors

B. Hayes· 3 shared E. H. Dao· 3 shared F. Poitevin· 3 shared M. Liang· 3 shared M. S. Hunter· 3 shared R. G. Sierra· 3 shared A. McGurk· 2 shared C. Gati· 2 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

B. Hayes

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Near-Physiological-Temperature Serial Femtosecond X-ray Crystallography Reveals Novel Conformations of SARS-CoV-2 Main Protease Active Site for Improved Drug Repurposing

S. Durdagi, C. Dag, B. Dogan, M. Yigin, T. Avsar, C. Buyukdag, I. Erol, F. B. Ertem, S. Calis, G. Yildirim, M. Orhan, O. Guven, B. Aksoydan, E. Destan, K. Sahin, , Sn

The paper determines two apo structures of SARS-CoV-2 main protease at near-physiological temperature using SFX and uses molecular simulations to analyze inhibitor binding for drug repurposing.

bioRxiv · Sep 9, 2020Biophysics

Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature

M. E. O'Sullivan, F. Poitevin, R. G. Sierra, C. Gati, E. H. Dao, Y. Rao, F. Aksit, H. Ciftci, N. Corsepius, R. Greenhouse, B. Hayes, M. S. Hunter, M. Liang, A. McGurk, P. Mbgam, , H. DeMirci

This study examines aminoglycoside interactions with the bacterial 30S ribosome at ambient and cryogenic temperatures, revealing temperature-sensitive conformational changes and new structural states.

bioRxiv · Jul 19, 2018Biophysics

Structure of the 30S ribosomal decoding complex at ambient temperature

E. H. Dao, F. Poitevin, R. G. Sierra, C. Gati, Y. Rao, H. I. Ciftci, F. Aksit, A. McGurk, T. Obrinski, P. Mgbam, B. Hayes, C. de Lichtenberg, F. Pardo-Avila, N. Corsepius, L. Zhang, , H. DeMirci

The paper reports an ambient-temperature X-ray crystal structure of the Thermus thermophilus 30S ribosomal decoding complex, showing consistency with cryogenic structures but with minor conformational variations.

bioRxiv · Mar 9, 2018Biophysics