Author

F. Alam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:E. coli· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

A. Robinson· 2 shared D. Huber· 2 shared I. R. Henderson· 2 shared J. Yule· 2 shared M. Jamshad· 2 shared A. Cupic· 1 shared A. Garcia-Sastre· 1 shared A. Marin· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. Robinson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pseudomonas aeruginosa increases the susceptibility of Candida albicans to amphotericin B in dual species biofilms

F. Alam, S. Blackburn, J. Correia, J. M. A. Blair, R. A. Hall

This paper shows that Pseudomonas aeruginosa increases the susceptibility of Candida albicans to amphotericin B in dual species biofilms by inducing oxidative stress and downregulating detoxification enzymes.

bioRxiv · Oct 19, 2022 · PreprintMicrobiology

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.

T. Kehrer, A. Cupic, C. Ye, S. Yildiz, M. Bouhhadou, N. A. Crossland, E. Barrall, P. Cohen, A. Tseng, T. Cagatay, R. Rathnasinghe, D. Flores, S. Jangra, F. Alam, N. Mena, , L. Miorin

This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.

bioRxiv · Oct 18, 2022Microbiology

Iron is a ligand of SecA-like metal-binding domains in vivo

T. Cranford Smith, M. Jamshad, M. Jeeves, R. A. Chandler, J. Yule, A. Robinson, F. Alam, K. A. Dunne, E. H. Aponte Angarita, M. Alanazi, C. Carter, I. R. Henderson, J. E. Lovett, P. Winn, T. Knowles, D. Huber

This study identifies iron as a ligand for SecA-like metal-binding domains in E. coli, showing that these domains bind iron preferentially and that azide disrupts this interaction.

bioRxiv · Apr 1, 2020Biochemistry

Genetic screen suggests an alternative mechanism for azide-mediated inhibition of SecA

M. Jamshad, R. Chandler, J. Yule, A. Robinson, F. Alam, K. Dunne, N. Nabi, I. R. Henderson, D. Huber

The paper uses a genetic screen to show azide inhibits SecA by causing it to backtrack in its ATPase cycle, disrupting membrane and metal cofactor binding.

bioRxiv · Aug 22, 2018 · PreprintMicrobiology