C. Carter

Deletion of wheat alpha-gliadins from chromosome 6D improves gluten strength and reduces immunodominant celiac disease epitopes

This study deletes wheat alpha-gliadins from chromosome 6D to improve gluten strength and reduce celiac disease epitopes.

Uropathogenic Escherichia coli population structure and antimicrobial susceptibility in Norfolk, UK

This study identifies clonal groups and resistance genes in Uropathogenic E. coli isolates from Norfolk, UK, revealing high rates of multi-drug resistance in hospital settings.

Post-secretory synthesis of a natural analog of iron-gall ink in the black nectar of Melianthus spp.

The paper identifies ellagic acid and iron as the black pigment in Melianthus nectar, showing post-secretory synthesis from gallic acid via peroxidase and iron(III).

Programming the lymph node immune response with Amphiphile-CpG induces potent cellular and humoral immunity following COVID-19 subunit vaccination in mice and non-human primates

This study evaluates an AMP-CpG adjuvant in combination with SARS-CoV-2 RBD as a subunit vaccine, showing enhanced T cell and cross-reactive antibody responses in mice and NHPs.

Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo

This study shows that blocking TGF-β signaling increases HIV-1 and SIV reactivation and boosts immune responses in infected individuals on ART.

Convergent evolution of a novel blood-red nectar pigment in vertebrate-pollinated flowers

This paper identifies a novel blood-red nectar pigment in two distantly related plants, showing convergent evolution through similar enzymatic pathways but different genes.

Iron is a ligand of SecA-like metal-binding domains in vivo

This study identifies iron as a ligand for SecA-like metal-binding domains in E. coli, showing that these domains bind iron preferentially and that azide disrupts this interaction.

Beyond type 1 regulatory T cells: co-expression of LAG3 and CD49b in IL-10-producing T cell lineages

The paper shows that LAG3 and CD49b co-expression is not exclusive to Tr1 cells but also occurs in IL-10-producing Treg and CD8+ T cells under specific conditions.

Insuperable Problems Of The Genetic Code Initially Emerging In An RNA World

The paper develops differential equations to explore the emergence of genetic coding from an RNA world, suggesting self-organisation principles over Darwinian selection as key to the origin of molecular information processing.